There is broad agreement that analysis of the human serum proteome has great potential for diagnosis and early detection of human disease. The challenges are immense given the complexity of the human proteome and the broad dynamic range in abundance of individual proteins. The key to unlocking this potential is the development of reproducible, sensitive and specific technology for proteomic analysis. Recent advances in technology suggest that this may now be feasible.
This study focuses on a unique serum bank collected from 200,000 postmenopausal women utilising existing and cutting edge proteomic technology and state-of-the-art bioinformatics. The results will provide a sound basis for assessing the screening and diagnostic potential of the serum proteome, establishing the identity of the discriminitive proteins and linking the findings to parallel genomic studies.